Alexis joined the crew of the USG O'Bannon along with her husband, Nolan Stross and their infant son. Alexis was first shown in Stross' flashback, arguing with him over their now crumbling marriage. They are ignored by Nolan claiming that she was ruining the only few minutes that he could spare with her and his son.
Alexis pointed out her suspicion of him having an affair with Isabel Cho. Nolan denied this, telling his wife that he brought them with him so they could be together which Alexis countered by telling her husband that she only came because she nagged him to take her. Nolan stubbornly left Alexis to comfort their crying son.
Later on, a hallucinating Stross entered their suite to protect her and their son, only to see the both of them as creatures. Stross first killed his son just before bashing Alexis' head, killing her. Cho walked in to see the horror that just unfolded, but Stross simply stated that his family was alive and safe and he only killed two monsters that are going to hurt them.
- Unlike her son who appeared as a Lurker in Stross' hallucination, Alexis did not appear as a known Necromorph. In fact, she simply appeared as a thin body with hollowed out facial features and empty eye sockets.
- Alexis was voiced by Erin Fitzgerald.
- Dead Space: Aftermath takes place three years before the events of Dead Space 2, the latter taking place in 2511.