Events of Dead Space 3
Alongside her co-pilot, Rosen, Locke aided in the rescue of Isaac Clarke from the New Horizons Lunar Colony during the Unitologist siege on the colony. Under Captain Robert Norton's orders, they entered ShockSpace, locking on to the shock beacon that Ellie Langford and her team took with them to Tau Volantis. When they arrived at Tau Volantis, the ship was bombarded and severely damaged by the mines. During the rush to safety, Rosen injured his leg and Locke tried to stave off the bleeding.
The destruction of the Eudora sent the room that Rosen and Locke are sealed in hurling through space towards the ruins of a Sovereign Colonies Armed Forces flotilla. Norton, Clarke and Carver managed to evade the mines and regain control of the compartment. They took shelter inside the CMS Roanoke while Locke attempted to stop Rosen from losing blood. Norton and Carver managed to help the two out of the room while Clarke attempted to locate Langford's S.O.S.
During Isaac's search of the ship, Norton's team encountered the Necromorphs and are forced to adopt Clarke's unorthodox methods to kill them. Once Langford and her team are found, the group made a combined effort in searching for parts that are necessary to repair the CMS Crozier. Once the shuttle was repaired, the crew made the perilous journey through the debris and mine field to reach the surface of Tau Volantis. As the shuttle started to fall apart, Locke's computer console exploded which ruptured the hull of the shuttle, pulling Locke out of the shuttle and into the atmosphere of the planet, killing her.
- Locke was both the first person of "EarthGov's last batallion" to die and the only member not to have their full name revealed.
- In her 3-D model files, however, she is listed as "Yvonne"
- Locke was the only member of Norton's crew who did not treat Isaac with hostility or uneasiness rather she did not interact with him directly at all.