- "As part of the Marker test program, Isaac, you helped make them. And today, you of all people, get to watch me set them free."
- —Jacob Arthur Danik to Isaac Clarke.
The active Red Marker after Jacob Danik destroyed its shroud.
The Luna Marker was a Red Marker located in the New Horizons Lunar Colony of Earth's moon. It appeared to be nearly as large as the Site 12 Marker and was covered in a shroud that prevented the Marker signal from spreading all around it. According to Jacob Arthur Danik, the shroud had a laboratory built within it, possibly similar to the one on Titan Station located in the Government Sector.
After Danik captured Isaac Clarke, he made him witness as he detonated the shroud and the lab around the Red Marker, exposing it. He then proceeded to attempt to execute Isaac, who managed to evade Danik's shot and fell down a shaft, into a pile of dead EarthGov security officers.
While Isaac blacked out, a Necromorph infestation began ravaging the colony, as the Marker signal leaked everywhere and began turning dead bodies into creatures which Isaac had to fight through.
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